HAEMATOLOGY RESEARCH GROUP
“Stressed” platelets in diabetes
Platelet hyperreactivity, the increased sensitivity of platelets to activate in response to stimuli, significantly predisposes individuals to cardiovascular events such as heart attack and stroke. Using unbiased proteomics analysis of human platelets, we identified that in platelets from individuals with type 2 diabetes have increased endoplasmic reticulum (ER) stress. We discovered that the beta subunit of the ER protein SEC61 is overexpressed in platelets with hyperglycemia and associates with increased cytoplasmic calcium. We aim to elucidate the connection between ER stress and platelet hyperreactivity.
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A. Heatmap of 100 highest fold change differences between diabetic and non-diabetic platelet proteins in the resting state. B. Correlation of the top 100 upregulated platelet proteins, in response to thrombin, with serum fructosamine. SEC61B was the only platelet protein significantly correlated with serum fructosamine (red dot).
Yvonne X Kong, et. al. bioRxiv 2024.02.20.581175; doi: https://doi.org/10.1101/2024.02.20.581175